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Ipamorelin vs Sermorelin: Decoding the Differences in Peptide Therapies
———————————————————————–
The growth hormone secretagogue receptor (GHSR) is the key target of both
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Molecular Structure
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Duration of Action
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Clinical Use Cases
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– Ipamorelin is favored by athletes and bodybuilders for its potent anabolic effect, rapid recovery facilitation, and minimal impact
on insulin sensitivity. It is also used in anti-aging
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Ipamorelin vs Sermorelin Comparison
———————————–
Feature Sermorelin Ipamorelin
Peptide Length 24 residues 5 residues
Origin GHRH analogue Synthetic ghrelin receptor agonist
Dose Range 200–500 µg/day 50–150 µg/day
Action Duration ~30 min – 1 h ~2–3 h
Injection Frequency 3–4 times daily 1 week before and after dianabol–2 times daily
Appetite Stimulation Mildly increases appetite No
significant effect
Insulin Sensitivity Impact May modestly decrease
insulin sensitivity Minimal impact
Side-Effect Profile Nausea, flushing, mild BP rise Injection site discomfort
only
Common Indications Diagnostic GH testing, elderly deficiency Athletic
performance, anti-aging
Key Takeaways
————-
Potency Matters – Ipamorelin is far more potent than sermorelin, requiring smaller
doses and fewer injections to achieve the same or greater
growth hormone stimulation.
Duration of Action Influences Protocols – The longer
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Safety Profiles Differ – Ipamorelin’s lack of appetite stimulation and minimal metabolic side effects make it a safer option for patients concerned about weight gain or insulin resistance.
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Clinical Context Guides Choice – For diagnostic purposes or mild therapeutic needs, sermorelin’s gradual effect can be advantageous.
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